Jessica M. Utts, PhD Sources:
Predictive Physiological Anticipation Preceding Seemingly Unpredictable Stimuli: A Meta-Analysis
This 2012 open-access meta-analysis in Frontiers in Psychology, co-authored by Jessica Utts with Julia Mossbridge and Patrizio Tressoldi, aggregated 26 reports of presentiment and predictive anticipatory activity (PAA) studies published 1978–2010 to test whether autonomic measures (skin conductance, heart rate, pupil dilation, EEG, fMRI) systematically differ in the seconds before a randomly delivered emotional or neutral stimulus arrives. The paper applies the same meta-analytic standards Utts had advocated for parapsychology since her 1991 Statistical Science review and represents one of the most cited single-paper meta-analyses in the contemporary psi literature.
Deeper dives — Utts:
Key findings
- The meta-analysis aggregated 26 reports of predictive anticipatory activity (PAA) studies published between 1978 and 2010, drawn from seven independent laboratories using autonomic measures such as skin conductance, heart rate, pupil dilation, EEG, and fMRI.1
- The pooled fixed-effects estimate indicated a small but statistically reliable anticipatory effect in the seconds before randomly-timed emotional vs. neutral stimuli, with the direction of the pre-stimulus physiological signal corresponding to the direction of the post-stimulus response.1
- The 2018 update by Mossbridge and Radin, expanding the corpus, reported an overall weighted effect size of d = 0.28 (95% CI: 0.18–0.38), consistent with the 2012 effect-size range.2
- Utts’s role on the paper, applying her established meta-analytic framework, treated PAA as a data-pattern question separable from the mechanism question: the aggregate effect warrants explanation regardless of whether a non-classical temporal mechanism is ultimately the correct account.3
- The authors explicitly framed the result as anomalous and in need of explanation rather than as confirmation of precognition, mirroring the data/mechanism separation Utts had maintained across her parapsychology publications since 1991.1
Overview
Predictive anticipatory activity (PAA), also called presentiment, refers to a pattern in which autonomic measures recorded in the seconds before a randomly-delivered stimulus systematically differ depending on the nature of the stimulus that will follow. If a participant cannot know which stimulus is coming (because target selection is computer-randomized and double-blinded), any reliable pre-stimulus differential is unexplained by conventional sensory or cognitive accounts. Mossbridge, Tressoldi, and Utts’s 2012 meta-analysis was the first formal cross-laboratory synthesis of this literature, applying standard meta-analytic methodology to a corpus that had grown over three decades but had never been quantitatively aggregated.1
Utts’s Role and the Data/Mechanism Frame
Utts’s contribution to the paper reflected her decades-long position that effect-size synthesis is the appropriate evaluative tool for small-effect parapsychological literatures, and that the data claim (“a reliable anomalous pattern is present”) must be evaluated separately from any mechanism claim (“the pattern reflects retrocausal information transfer”).3 The 2012 paper consistently adheres to this separation: it reports the pooled effect size, characterizes heterogeneity, addresses publication bias through standard funnel-plot and trim-and-fill methods, and explicitly leaves open the question of what mechanism, if any, generates the observed pattern. The paper’s conclusion that the effect is “in need of explanation” echoes the language Utts used in her 1991 Statistical Science paper and her 1995 AIR review of remote viewing.
Methodology and Inclusion Criteria
The meta-analysis followed PRISMA-style reporting conventions, with inclusion criteria specifying that studies must use a within-subjects design comparing pre-stimulus physiology between trial types, that target stimuli must be randomly assigned (computer-controlled), and that the pre-stimulus epoch must be measured before any sensory cue indicating stimulus type could reach the participant.1 Twenty-six reports met criteria; effect sizes were computed where the original papers provided sufficient statistics, and where they did not, effect sizes were estimated from reported test statistics using standard conversion formulas.
What “Randomly Delivered” Means in Practice
The methodological linchpin of any PAA study is that the participant cannot know, by ordinary sensory or inferential means, which stimulus will arrive. The 2012 paper’s inclusion criteria required computer-controlled randomization of trial type, with the random seed determined by physical or pseudorandom processes inaccessible to the experimenter at trial time, and the experimenter blinded to the upcoming stimulus during the pre-stimulus epoch. Studies failing these criteria, including any with operator-paced trial initiation or any in which a sensory cue (auditory click, visual flicker) could indicate stimulus type during the pre-stimulus window, were excluded from the primary synthesis.1 The authors addressed the specific concern that within-session order effects (expectation following several similar trials in a row) could mimic anticipation by noting that constituent studies used randomization schemes that minimized streak structure.
Publication Bias Assessment
The meta-analysis applied standard publication-bias diagnostics including funnel-plot inspection and trim-and-fill analysis. The authors reported that funnel-plot asymmetry was modest and that trim-and-fill adjustments reduced but did not eliminate the aggregate effect.1 They acknowledged that publication bias remains a structural concern in any small-effect literature and that the fail-safe N calculations they reported (analogous to those Utts used in her 1991 review) are conservative metrics with known limitations. The 2018 update by Mossbridge and Radin re-examined these bias diagnostics with a larger corpus and reported similar conclusions: bias is detectable but insufficient to nullify the aggregate effect.2
Findings: Effect Size and Heterogeneity
The 2012 paper reported a small but statistically reliable pooled effect across the 26 reports, with the direction of pre-stimulus physiological activity systematically corresponding to the direction of the post-stimulus response. Effect-size estimates fell in the range Utts had treated as scientifically meaningful when replicated across independent laboratories in her 1991 Statistical Science review.1 Heterogeneity across studies was non-trivial but within the range typical for psychological meta-analyses, consistent with the methodological diversity of the underlying paradigms (skin conductance, heart rate, pupil dilation, EEG, fMRI).
The 2018 Update: Convergent Estimates
Mossbridge and Radin’s 2018 update2 expanded the 2012 corpus with newer studies and reported a weighted overall effect size of d = 0.28 (95% CI: 0.18–0.38). This estimate is consistent in magnitude with the 2012 paper’s findings and falls within the small-effect range Utts characterized as the typical signature of parapsychological literatures. The convergence between the 2012 and 2018 estimates, despite expansion of the sample and several years of additional methodological criticism, partially addresses the concern that the 2012 result was an artifact of the specific studies available at that time.
Modern Context
The presentiment / predictive-anticipatory-activity literature Utts addressed in commentary connects to a small-effect-size physiological meta-analysis methodology that has been examined in mainstream metascience. Ioannidis (2005, PLoS Medicine; 10.1371/journal.pmed.0020124) provided the canonical mainstream framing for why small-effect literatures with researcher degrees of freedom are vulnerable to false-positive accumulation, a concern directly relevant to PAA meta-analyses where the per-trial physiological differential is by definition small. The Mossbridge, Tressoldi, and Utts (2012) meta-analysis (Frontiers in Psychology; 10.3389/fpsyg.2012.00390) is itself the contemporary methodological standard for PAA effect-size estimation within the parapsychological literature, and has been engaged by mainstream physiological-anticipation researchers in subsequent expectation-effects work.
Discussion and Implications
The 2012 paper consistently maintained the data/mechanism separation that has been Utts’s hallmark across her parapsychology publications. The aggregate effect is reported as anomalous and in need of explanation; the authors do not claim it confirms a retrocausal or precognitive mechanism. They identify several candidate explanations, ranging from undetected sensory leakage and statistical artifact through to genuinely anomalous information transfer, and note that distinguishing among these candidates requires additional preregistered, multi-laboratory replication using uniform methodology.1
What Would Settle the Question
The methodological standard the 2012 paper points toward, but does not itself satisfy, is a preregistered, adversarial-collaboration replication using a single uniform protocol across multiple independent laboratories. Such a study would address the residual heterogeneity concern, the publication-bias concern, and the file-drawer concern simultaneously, and would either confirm the aggregate effect under maximally controlled conditions or fail to do so. The 2018 update partially advances this agenda but does not constitute a single uniform replication; the question of whether the PAA pattern survives adversarial preregistered replication remains open.2
Skeptical Critiques and Discussion
Critique 1: The aggregate effect reflects subtle expectation or anticipatory artifacts not adequately controlled in constituent studies
Skeptic source: A standard critique of the PAA literature, addressed but not fully resolved by the 2012 paper, holds that human anticipation of stimulus structure, including subtle awareness of session-pacing rhythms, residual sensory cues from equipment, or unconscious detection of streak patterns in pseudorandom sequences, could produce systematic pre-stimulus differentials that mimic anomalous anticipation without requiring any non-classical mechanism.4
Response: The 2012 paper’s inclusion criteria addressed several specific versions of this concern: computer-controlled randomization eliminated operator-paced sources of leakage; double-blinded designs prevented experimenter cueing; and constituent studies using counterbalanced trial orders reduced streak-detection vulnerability.1 The authors acknowledged that no meta-analysis can fully rule out subtle artifacts in the underlying studies and that adversarial preregistered replication is the appropriate next step. The 2018 update reports that the effect persists with newer studies that incorporated additional anti-cueing controls.2
Analysis. The artifact concern is methodologically legitimate; the meta-analysts’ response addresses several specific mechanisms but cannot fully eliminate the possibility that subtle uncontrolled anticipatory cues remain in some subset of constituent studies. Adversarial replication is the appropriate resolution path.
Critique 2: Publication bias and selective reporting can fully account for the observed aggregate effect
Skeptic source: A common critique of small-effect psi meta-analyses is that the file-drawer problem, combined with selective outcome reporting within published studies (researcher degrees of freedom in choosing which physiological channel, time window, or contrast to report), can manufacture aggregate effects of the magnitude reported without any underlying signal.4
Response: The 2012 paper applied funnel-plot inspection, trim-and-fill, and fail-safe N analysis to address these concerns and reported that publication bias was detectable but modest in magnitude, and that the number of file-drawer null studies required to nullify the aggregate effect was implausibly large.1 The authors acknowledged that fail-safe N is a conservative metric with known limitations (Utts had documented these limitations herself in her 1991 review) and that the residual concern is real. The appropriate response is preregistration of future PAA studies with explicit specification of the physiological channel, time window, and contrast in advance, a standard the field has increasingly adopted post-2012.
Analysis. Publication bias is a real concern; the meta-analysts’ diagnostics partially but not fully address it. The post-2012 movement toward preregistered PAA designs is the methodologically appropriate response.
References
- Mossbridge, J. A., Tressoldi, P. E., & Utts, J. M. (2012). Predictive physiological anticipation preceding seemingly unpredictable stimuli: A meta-analysis. Frontiers in Psychology, 3, 390. https://doi.org/10.3389/fpsyg.2012.00390 R001 [Mossbridge 2012] ↩︎
- Mossbridge, J. A., & Radin, D. (2018). Predictive physiological anticipatory activity preceding seemingly unpredictable stimuli: An update of Mossbridge et al’s meta-analysis. F1000Research. R002 [Mossbridge 2018] ↩︎
- Utts, J. (1991). Replication and meta-analysis in parapsychology. Statistical Science, 6(4), 363–403. https://doi.org/10.1214/ss/1177011577 R003 [Utts 1991] ↩︎
- Schwarzkopf, D. S. (2014). We should have seen this coming. Frontiers in Human Neuroscience, 8, 332. R004 [Schwarzkopf 2014] ↩︎
Deeper dives — Utts:
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